Projects:

Neuronal regulation of bone remodeling and cancer
NF1 pseudoarthrosis
Orphan projects

Laboratory Personnel:

• Yun Ma
  Post-Doctoral Fellow
• Weixi Wang
  Post-Doctoral Fellow
• Preston James Cambell
  Graduate Student
• Brent Livesay
  Research Assistant I
• Melissa Makar
  Emphasis student
  

Research Techniques:

• Molecular Biology

• Biochemistry

• Mammalian bone cell culture

• Immunohistochemistry (frozen, paraffin, plastic)

• Static and Dynamic Bone Histomorphometry (Bioquant)

• 3D-Microtomography (Scanco40)

• Bone fracture (Einhorn method)

Recent Publications:

1. A. Dumestre, F. Elefteriou & M. Goyffon, 1996, Toxins and future prospectives (In French). Biofutur 168.
2. F. Elefteriou, J.Y. Exposito, R. Garonne and C. Lethias, 1997. Characterization of the bovine tenascin-X. J Biol Chem 272:22866-74.
3. F. Elefteriou, J.Y. Exposito, R. Garrone and C. Lethias, 1999. Cell adhesion to tenascin-X: mapping of cell adhesive sites and identification of integrin receptors. Eur. J. Biochem. 263:840-48.
4. C. Lethias, F. Elefteriou, G. Parsiegla, J.Y. Exposito, R. Garrone, 2001. Identification and characterization of a conformational heparin-binding site involving two fibronectin type III modules of bovine tenascin-X. J Biol Chem 276:16432-38.
5. F. Elefteriou, J.Y. Exposito, R. Garrone, C. Lethias, 2001. Binding of tenascin-X to decorin. FEBS Lett 495 (1-2):44-47.
6. S. Takeda*, F. Elefteriou*, R. Levasseur, X. Liu , X. Zhao, K.L. Parker, D. Armstrong, P. Ducy and G. Karsenty, 2002. Leptin regulates bone formation via the sympathetic nervous system. Cell 111: 305-17 (*co-first authors).
7. R. Levasseur, R. Barrios, F. Elefteriou, D.A. Glass II, M.W. Lieberman and G. Karsenty, 2003. Reversible skeletal abnormalities in g-glutamyl transpeptidase-deficient mice. Endocrinology 114(7):2761-64.
8. S. Takeda, F. Elefteriou and G. Karsenty, 2003. Common Endocrine Control of Body Weight, Reproduction and Bone Mass. Annual Review of Nutrition 23.
9. F. Elefteriou and G. Karsenty, 2003. Bone mass regulation by leptin: from the hypothalamus to osteoblasts. Pathologie Biologie, 52(3):148-53 (In french).
10. F. Elefteriou, S. Takeda, X. Liu, D. Armstrong and G. Karsenty, 2003. MSG-sensitive hypothalamic neurons contribute to the control of bone mass. Endocrinology 144(9):3842-47.
11. F. Elefteriou and P. Ducy, 2003. The big tree hiding the forest (In french). Medecine/Sciences 19:391-93.
12. Y. Cui, L. Huang, F. Elefteriou, G. Yang, J.M. Shelton, J.E. Giles, O.K. Oz, T. Pourbahrami, C.Y.H. Lu, J.A. Richardson, G. Karsenty, and C. Li, 2004. Essential role of STAT3 in body weight and glucose homeostasis, Mol Cell Biol 24(1):258-69.
13. F. Elefteriou, S. Takeda, K. Ebihara, J. Magre, N. Patano, C. Ae Kim, Y. Ogawa, X. Liu, W.J. Craigen, J.J. Robert, C Vinson, K. Nakao, J. Capeau and G. Karsenty, 2004. Bone mass varies in mammals according to serum leptin levels.  PNAS 101(9):3258-63.
14. T.A. Cock, Back J, F. Elefteriou, G . Karsenty, P. Kastner, S. Chan & J. Auwerx, 2004 Enhanced bone formation in lipodystrophic PPARhyp/hyp mice relocates haematopoiesis to the spleen. EMBO Report 5(10):1007-12.
15. F. Elefteriou , J. D. Ahn, S. Takeda, M. Starbuck, X. Yang, X. Liu, H. Kondo, W. G. Richards, T. W. Bannon, M. Noda, K. Clement, C. Vaisse and G. Karsenty. 2005. Leptin regulation of bone resorption via the sympathetic nervous system and CART, Nature 434:514-20.
16. F. Elefteriou. 2005. Neuronal signaling and the regulation of bone remodeling. Cell. Mol. Life Sci. 62:2339:49.
17. G.R. Mundy, F. Elefteriou, 2006. Boning Up on Ephrin Signaling. Cell 126:441-443.
18. F. Elefteriou, D. Benson, H. Sowa, M. Starbuck, X. Liu, D. Ron, L.F. Parada  and G. Karsenty, 2006. ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae, Cell Metabolism 4(6):441-451.
19. G.R. Mundy, B.O. Oyajobi, G. Gutierrez, J.A. S.terling, S. Padalecki, F. Elefteriou, M. Zhao. Cytokines and bone remodeling. In: Osteoporosis 3rd Edition, Marcus R, Feldman D, Nelson D, Rosen CJ (eds), Elsevier, 1(13), pp. 491-515, 2007
20. M.S. Patel and F. Elefteriou, 2007. The new field of neuroskeletal biology. Calcified Tissue International, 80(5):337-47.
21. G. Karsenty and F. Elefteriou. 2008. 7th edition of the ASBMR Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism.
22. M. K. Singh, F. Elefteriou and G. Karsenty, 2008. CART may regulate bone remodeling as a circulating molecule, Endocrinology, in press.