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Osteoblast-specific transcription of BMP-2: Interaction of 5’ promoter region and 3’ distant ECR sequence of BMP-2 gene |
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| Recently, Dr. Douglas Mortlock (Center for Human Genetics Research, Vanderbilt) has identified a distant 3’ genomic sequence of mouse BMP-2 gene, namely ECR1, and demonstrated that this sequence controls BMP-2 transcription specifically in osteoblasts. We found that this ECR1 sequence mediates Gli2 transactivation of BMP-2 promoter activity, suggesting that there might be an interaction between the 5’ promoter region and the 3’ distant ECR1 region in controlling BMP-2 transcription in osteoblasts.
This is a collaborative research project with Dr. Mortlock’s lab. We will explore the interaction of Gli proteins and ECR1 region and determine the potential function of this cis-element in BMP-2 gene regulation and bone formation. LacZ reporter transgenic mice will be used.
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The VUMC Center for Bone Biology is a member of the VUMC Department of Medicine in the Division of Clinical Pharmacology. |
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